Title of article
Direct, practical, and powerful crossed aldol additions between ketones and ketones or aldehydes utilizing environmentally benign TiCl4–Bu3N reagent
Author/Authors
Yoo Tanabe، نويسنده , , Noriaki Matsumoto، نويسنده , , Takahiro Higashi، نويسنده , , Tomonori Misaki، نويسنده , , Tomotaka Itoh، نويسنده , , Misako Yamamoto، نويسنده , , Kumi Mitarai، نويسنده , , Yoshinori Nishii، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
12
From page
8269
To page
8280
Abstract
An efficient TiCl4–Bu3N—(cat. TMSCl)-promoted aldol addition between ketones and ketones or aldehydes was performed. This environmentally benign method is advantageous from a green chemical viewpoint with regard to yield, substrates variation, reagent availability, and simple procedures. This method was applied to a short step formal synthesis of (R)-muscone, a natural macrocyclic musk.
Keywords
titanium chloride , aldol addition , tributylamine , Chlorotrimethylsilane , muscone
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1083536
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