Title of article
A novel synthesis of 3(R)-HETE, 3(R)-HTDE and enzymatic synthesis of 3(R),15(S)-DiHETE
Author/Authors
Natalia V Groza، نويسنده , , Igor V Ivanov، نويسنده , , Stepan G Romanov، نويسنده , , Galina I Myagkova، نويسنده , , Santosh Nigam، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
5
From page
9859
To page
9863
Abstract
3(R)-HETE and 3(R)-HTDE were prepared by cross-coupling of methyl 3(R)-hydroxyhex-5-ynoate either with 1-bromo-2,5,8-tetradecatriyne or 1-bromo-2-octyne followed by catalytic hydrogenation of the skipped triple bonds formed using Lindlarʹs catalyst. Enzymatic synthesis of 3(R),15(S)-DiHETE was accomplished by soybean LOX-1 using 3(R)-HETE as a substrate.
Keywords
Coupling reactions , Total synthesis , lipoxygenases , DiHETE , 3-hydroxy-oxylipins
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1083700
Link To Document