Title of article
Studies directed toward the total synthesis of pinnatoxin A: synthesis of the 6,5,6-dispiroketal (BCD ring) system by double hemiketal formation/hetero-Michael addition strategy
Author/Authors
Seiichi Nakamura، نويسنده , , Jun Inagaki، نويسنده , , Masashi Kudo، نويسنده , , Tomohiro Sugimoto، نويسنده , , Kohei Obara، نويسنده , , Makoto Nakajima، نويسنده , , Shunichi Hashimoto، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
22
From page
10353
To page
10374
Abstract
An efficient, highly stereoselective synthesis of the C10–C26 portion of pinnatoxin A has been achieved, wherein the key step is a highly stereoselective construction of the 6,5,6-dispiroketal (BCD ring) system by an intramolecular hetero-Michael addition of a hemiketal alkoxide reversibly formed under the influence of lithium methoxide.
Keywords
dispiroketal , Hetero-Michael addition , hemiketal formation
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1083759
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