Title of article
An efficient method for the stereoselective synthesis of cis-3-substituted prolines: conformationally constrained α-amino acids
Author/Authors
Céline Flamant-Robin، نويسنده , , Qian Wang، نويسنده , , Angèle Chiaroni، نويسنده , , N. André Sasaki، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
10
From page
10475
To page
10484
Abstract
An efficient synthesis of enantiomerically pure cis-3-substituted prolines is reported. Key steps involve the stereoselective organocuprate addition to the (E)-α,β-unsaturated ester , obtained from the Garnerʹs aldehyde, and expedient oxidation–cyclization sequences.
Keywords
3-cis-substituted proline , organocuprate , conformationally constrained ?-amino acid , Stereoselective
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1083772
Link To Document