Novel taxoids from the Chinese yew Taxus yunnanensis

Six new taxoids, taxuyunnanines W (), X (), Y (), Z (), 10-deacetyl-10-(β-glucopyranosyl)-yunnanxane (), and 7-(β-xylosyl)-N-methyl-taxol C (), as well as taxuchin B () and yunnanxane (), have been isolated from the bark of Taxus yunnanensis. Compounds and were characterized as 11(15→1)-abeo taxoids containing an orthoester group, which have not been reported from any Taxus plants to date; isolates and are the examples of taxanes having a tetrahydronfuran ring, being reported only for the second time; and is the first natural 6/8/6 skeletal type taxane glucosidic form. This is also the first report of a co-occurrence of xylosidation and N-methylation in a taxane (). Compound is the only known chlorine-containing taxane found in nature thus far, and is being reported from this plant for the first time. The structures were determined by spectroscopic and chemical means including 1D and 2D NMR spectra.