Title of article
The application of vinylogous iminium salt derivatives to the synthesis of Ningalin B hexamethyl ether
Author/Authors
John T Gupton، نويسنده , , Stuart C Clough، نويسنده , , Robert B Miller، نويسنده , , John R Lukens، نويسنده , , Charlotte A Henry، نويسنده , , René P.F Kanters، نويسنده , , James A. Sikorski، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
9
From page
207
To page
215
Abstract
A vinylogous iminium salt derivative has been used to prepare a 2,3,4-trisubstituted pyrrole synthon in a regioselective, efficient and convenient manner. This pyrrole synthon was subsequently converted to the multidrug-resistant (MDR) reversal agent, Ningalin B hexamethyl ether, via alkylation, hydrolysis and oxidative lactonization steps. This methodology provides an alternative pathway to this important class of pyrrole containing marine natural products.
Keywords
chloropropeniminium salt , ?-chloroenal , trisubstituted pyrrole , Ningalin B
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1083794
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