Author/Authors :
Xiangjiu He، نويسنده , , Jiankuan Li، نويسنده , , Hao Gao، نويسنده , , Feng Qiu، نويسنده , , R.; Ke Hu، نويسنده , , Xiangmin Cui، نويسنده , , Xinsheng Yao، نويسنده ,
Abstract :
Four new sulfonate metabolites of andrographolide, 14-deoxy-12(R)-sulfo andrographolide (Metabolite ), 14-deoxy-12(S)-sulfo andrographolide (Metabolite ), 14-deoxy-12(R)-sulfo-9(S)-andrographolide (Metabolite ) and 14-sulfo isoandrographolide (Metabolite ), were isolated from urine and feces in rats. Their structures were elucidated by chemical and spectroscopic analyses. These four metabolites were formed through a rare metabolic reaction and were all new compounds.
