Title of article
An alternative approach towards novel heterocycle-fused 1,4-diazepin-2-ones by an aromatic amidation protocol
Author/Authors
Arkaitz Correa، نويسنده , , M.Teresa Herrero، نويسنده , , Imanol Tellitu، نويسنده , , Esther Dom??nguez، نويسنده , , Isabel Moreno، نويسنده , , Raul SanMartin، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
8
From page
7103
To page
7110
Abstract
The synthesis of new 1,4-diazepin-2-one derivatives starting from glycine or alanine aminoacids is presented. The key cyclization step includes the PIFA mediated formation of N-acylnitrenium ions and their subsequent intramolecular trapping by an (hetero)aromatic ring. The so-promoted aromatic amidation process takes place without loss of enantiomeric purity when optically pure methoxyamide precursors are employed.
Keywords
hypervalent iodine , Heterocycles , Cyclizations , N-acylnitrenium , diazepin-2-ones
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1084256
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