Title of article
Strategies for the synthesis of N-(azacycloalkyl)bisindolylmaleimides: selective inhibitors of PKCβ
Author/Authors
Margaret M. Faul and، نويسنده , , John L. Grutsch، نويسنده , , Michael E. Kobierski، نويسنده , , Michael E. Kopach، نويسنده , , Christine A. Krumrich، نويسنده , , Michael A. Staszak، نويسنده , , Uko Udodong، نويسنده , , Jeffrey T. Vicenzi، نويسنده , , Kevin A. Sullivan، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
15
From page
7215
To page
7229
Abstract
N-(Azacycloalkyl)bisindolylmaleimides have been identified to be selective inhibitors of PKCβ. This manuscript will describe the synthetic approaches employed to prepare this class of compounds that resulted in development of efficient methods for preparation of N-(azacycloalkyl) indole , indole-3-acetamide and indole-3-glyoxylate ester derivatives.
Keywords
Angiogenesis , N-(azacycloalkyl)bisindolylmaleimides , vascular endothelial growth factor
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1084269
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