Title of article
Diastereoselective synthesis of 2-substituted-piperidin-4-ones as convenient precursors for an asymmetric approach to carbacephams
Author/Authors
Achille Barco، نويسنده , , Nikla Baricordi، نويسنده , , Simonetta Benetti، نويسنده , , Gisella Biondini، نويسنده , , Carmela De Risi، نويسنده , , Gian Piero Pollini، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
6
From page
8439
To page
8444
Abstract
Optically active carbacephams can be efficiently prepared generating the β-lactam ring on 2-substituted-piperidin-4-ones. These can, in turn, be prepared diastereoselectively through a Michael–Michael reaction sequence initiated by benzylamine on precursors derived by Wittig reaction between serinals and 4-[(4-methylphenyl)sulfonyl]-1-(triphenylphosphoranylidene)-2-butanone.
Keywords
diastereoselection , 2-substituted-piperidin-4-ones , carbacephams
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1084399
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