Title of article
Synthesis of highly substituted tetrahydropyrans: preparation of the C20–C28 moiety of phorboxazoles
Author/Authors
Tushar K Chakraborty، نويسنده , , V.Ramakrishna Reddy، نويسنده , , T.Jagadeshwar Reddy، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
10
From page
8613
To page
8622
Abstract
A propionate-derived polyketide building block whose 2-methyl-1,3-diol moiety was built by a Ti(III)-mediated ring opening reaction of a trisubstituted 2,3-epoxy alcohol precursor was employed as a common starting material for the syntheses of highly substituted tetrahydropyrans , the first one being the C20–C28 fragment of cytotoxic natural products, phorboxazoles.
Keywords
epoxy alcohols , 2-methyl-1 , Sharpless epoxidation , 3-diol , phorboxazoles , Epoxide opening
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1084415
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