Title of article
Hydro-de-halogenation and consecutive deprotection of chlorinated N-amido-pyrrolidin-2-ones with Raney-Ni: an effective approach to gabapentin
Author/Authors
Rita Cagnoli، نويسنده , , Franco Ghelfi، نويسنده , , Ugo M Pagnoni، نويسنده , , Andrew F Parsons، نويسنده , , Luisa Schenetti، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
10
From page
9951
To page
9960
Abstract
The benzoylamino group was identified as a useful radical cyclization auxiliary that can be smoothly removed on hydro-de-halogenation of chlorinated N-substituted-pyrrolidin-2-ones with Raney-Ni. This methodology was successfully implemented in a new and appealing route to the anti-epileptic drug gabapentin.
Keywords
Hydrazides , Cyclizations , Hydrogenolysis , pyrrolidinones
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1084542
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