Title of article
Synthesis of (+)-goniothalamin and its enantiomer by combination of lipase catalyzed resolution and alkene metathesis
Author/Authors
Eirik Sundby، نويسنده , , Lars Perk، نويسنده , , Thorleif Anthonsen، نويسنده , , Arne J?rgen Aasen، نويسنده , , Trond Vidar Hansen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
521
To page
524
Abstract
(+)-Goniothalamin has been synthesized by lipase catalyzed resolution of (1E)-1-phenylhexa-1,5-dien-3-ol using vinyl acrylate as acyl donor followed by ring closing metathesis of the formed (1R)-1-[(E)-2-phenylvinyl]but-3-enyl acrylate. The unreacted alcohol from the resolution, (1E,3S)-1-phenylhexa-1,5-dien-3-ol, was esterified non-enzymatically, and used for synthesis of (−)-goniothalamin.
Keywords
(+)-Goniothalamin , (?)-Goniothalamin , Candida antarctica lipase B , Resolution , Alkene metathesis , Grubbsי catalyst
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1084682
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