Title of article
Novel synthetic route of aryl-aminopyrazine
Author/Authors
Masaki Kuse، نويسنده , , Nobuhiro Kondo، نويسنده , , Yuki Ohyabu، نويسنده , , Minoru Isobe and Kunio Miki، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
6
From page
835
To page
840
Abstract
We report a novel synthetic route of aryl-aminopyrazine through a new cyclization reaction by using a hydroxylamine. Starting from Boc-glycine and aminonitrile, the aminopyrazine ring was prepared in several steps. After trifluoromethane sulfonylation of the aminopyrazinone, the resultant triflate was subjected to Suzuki–Miyaura coupling reaction with aryl boronic acid to afford coelenteramine.
Keywords
Aminopyrazine , Suzuki coupling , Hydroxylamine
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1084759
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