Title of article :
A highly diastereoselective synthesis of a 1-β-methylcarbapenem intermediate using titanium enolate of 2′-hydroxypropiophenone
Author/Authors :
You-Sang Lee، نويسنده , , Won-Keun Choung، نويسنده , , Kyoung-Hoon Kim، نويسنده , , Tae Won Kang، نويسنده , , Deok-Chan Ha، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
A key 1-β-methylcarbapenem intermediate is synthesized from a highly diastereoselective condensation between the titanium enolate of 2′-hydroxypropiophenone with 4-acetoxy-β-lactam followed by ozonolysis of the resulting ketone to the carboxylic acid.
Keywords :
enolates , azetidinones , carbapenems , Condensation , Stereoselective , Ozonolysis
Journal title :
Tetrahedron
Journal title :
Tetrahedron
