Title of article
Asymmetric synthesis of 3(S),17-dihydroxytanshinone
Author/Authors
Jianhua Xie and Jiangang Zhang، نويسنده , , Wenhu Duan، نويسنده , , Junchao Cai، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
5
From page
1665
To page
1669
Abstract
The first synthesis of 3(S),17-dihydroxytanshinone was achieved by ultrasound promoted Diels–Alder reaction of the protected 3-hydroxymethyl-4,5-benzofurandione with a vinylcyclohexene derivative. Bioassay showed that the synthetic 3(S),17-dihydroxytanshinone was active in vitro against HL-60 tumor cell line by MTT method.
Keywords
Diels–Alder cycloaddition , Total synthesis , Ultrasound , Natural product , Tanshinone diterpene , Antitumor , Dihydroxytashinone
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1084909
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