New pyrophosphate analogues: a facile access to N-(O-alkyl-sulfamoyl)phosphoramidic acids via a simple and quantitative reaction of N-(O-alkylsulfamoyl)trimethylphospha-λ5-azene with bromotrimethylsilane and water

A new strategy to prepare pyrophosphate analogues through selective and quantitative cleavage of N-(O-alkylsulfamoyl)trialkylphospha-λ5-azene esters (R–O–SO2–NP(OR′)3) has been developed. Using pure bromotrimethylsilane, N-(O-alkyl-sulfamoyl)tristrimethylsilylphospha-λ5-azenes (R–O–SO2–NP(OSiMe3)3) have been easily obtained as intermediates. N-(O-Alkyl-sulfamoyl)phosphoramidic acids (R–O–SO2–NH–P(O)(OH)2) have been formed quantitatively by hydrolysis of the silylated intermediates.