Title of article
Synthesis of a proline-rich [60]fullerene peptide with potential biological activity
Author/Authors
Panagiota Sofou، نويسنده , , Yiannis Elemes، نويسنده , , Eugenia Panou-Pomonis، نويسنده , , Athanassios Stavrakoudis، نويسنده , , Vassilios Tsikaris، نويسنده , , Constantinos Sakarellos، نويسنده , , Maria Sakarellos-Daitsiotis، نويسنده , , Michele Maggini، نويسنده , , Fernando Formaggio، نويسنده , , Claudio Toniolo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
6
From page
2823
To page
2828
Abstract
A proline-rich [60]fullerene peptide was synthesized by use of (i) a 1,3-dipolar cycloaddition of an N-substituted glycine derivative to [60]fullerene, (ii) esterification of the isolated alcohol with the C-terminal amino acid of the desired peptide sequence, and finally (iii) coupling of the remaining hexapeptide to give the final product as a TFA salt, with oxidized methionine. Product was found to be biologically active against sera from MCTD and SLE patients (ELISA experiment).
Keywords
Fullerenes , 3-dipolar cycloadditions , Fullerene peptides , azomethine ylides , 1
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1085158
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