Title of article :
Pentaspiranes and hexaspiranes with 1,3-dioxane or 1,3-oxathiane rings: synthesis and stereochemistry
Author/Authors :
Anamaria Terec، نويسنده , , Ion Grosu، نويسنده , , Eric Condamine، نويسنده , , Livain Breau، نويسنده , , Gérard Plé، نويسنده , , Yvan Ramondenc، نويسنده , , Fernande D Rochon، نويسنده , , Valérie Peulon-Agasse، نويسنده , , Dorina Opris، نويسنده ,
Abstract :
The synthesis and stereochemistry of the first reported pentaspiro- and hexaspiro-1,3-dioxane and polyspiro-1,3-oxathiane (from dispiro to hexaspiro) derivatives are described. The crystal structures of a dispiro- and tetraspiro-1,3-oxathiane were determined by X-ray diffraction methods. NMR and chiral column HPLC investigations in solution revealed flexible and semiflexible structures for which syn–anti, cis–trans and d,l isomers were observed.
