Author/Authors :
Hyeung-geun Park، نويسنده , , Jihye Lee، نويسنده , , Myoung Joo Kang، نويسنده , , Yeonju Lee، نويسنده , , Byeong-Seon Jeong، نويسنده , , Jeonghee Lee، نويسنده , , Mi-Sook Yoo، نويسنده , , Mi-Jeong Kim، نويسنده , , Sea-hoon Choi، نويسنده , , Sang-sup Jew، نويسنده ,
Abstract :
Practical synthesis of (±)-α-alkylserines and tert-butyl benzamidoacrylate from tert-butyl 2-phenyl-2-oxazoline-4-carboxylate () were developed. The α-alkylation and β-elimination of are dramatically dependent upon base conditions. The phase-transfer catalytic condition bearing solid KOH in toluene gives α-alkylation (up to >99%), and t-BuOK in DMF gives β-elimination (98%).
