Title of article
An unusual base-dependent α-alkylation and β-elimination of tert-butyl 2-phenyl-2-oxazoline-4-carboxylate: practical synthesis of (±)-α-alkylserines and tert-butyl benzamidoacrylate
Author/Authors
Hyeung-geun Park، نويسنده , , Jihye Lee، نويسنده , , Myoung Joo Kang، نويسنده , , Yeonju Lee، نويسنده , , Byeong-Seon Jeong، نويسنده , , Jeonghee Lee، نويسنده , , Mi-Sook Yoo، نويسنده , , Mi-Jeong Kim، نويسنده , , Sea-hoon Choi، نويسنده , , Sang-sup Jew، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
7
From page
4243
To page
4249
Abstract
Practical synthesis of (±)-α-alkylserines and tert-butyl benzamidoacrylate from tert-butyl 2-phenyl-2-oxazoline-4-carboxylate () were developed. The α-alkylation and β-elimination of are dramatically dependent upon base conditions. The phase-transfer catalytic condition bearing solid KOH in toluene gives α-alkylation (up to >99%), and t-BuOK in DMF gives β-elimination (98%).
Keywords
?-Alkylserines , Phase-transfer catalytic alkylation , Benzamidoacrylate
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1085476
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