Title of article :
2-Substituted-3,7-dinitro-11-oxatricycloundec-9-ene: an approach towards the synthesis of Ergot alkaloids
Author/Authors :
Shatha Younis Mahmood، نويسنده , , Marie-Christine Lallemand، نويسنده , , Lina Sader-Bakaouni، نويسنده , , Olivier Charton، نويسنده , , Philippe Vérité، نويسنده , , Hanh Dufat، نويسنده , , Francois Tillequin، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
A simple and versatile method for the preparation of various ergoline or secoergoline skeleton, using 2-substituted-3,7-dinitro-11-oxatricycloundec-9-ene as key intermediates, is described. The key step involves an IMDAF reaction with an excellent stereocontrol. This novel synthetic route provides new cycloadducts as useful scaffolds for Ergot alkaloids synthesis.
Keywords :
Secoergoline , Lysergic acid , IMDAF , Ergot alkaloids , Ergoline , Oxatricycloundec-9-ene compounds
Journal title :
Tetrahedron
Journal title :
Tetrahedron
