Title of article
Stabilization of DNA duplexes by covalently-linked peptides
Author/Authors
Vicente March?n، نويسنده , , Laurent Debéthune، نويسنده , , Enrique Pedroso، نويسنده , , Anna Grandas، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
9
From page
5461
To page
5469
Abstract
The hybridization properties of various peptide–oligonucleotide hybrids were assessed from UV thermal denaturation experiments. Analysis of these and other published data suggests that peptide chains, both hydrophobic and positively charged, generally have a clear stabilizing effect on short-chain oligonucleotide duplexes.
Keywords
Melting temperature , nucleopeptide , Peptide–oligonucleotide conjugate , Duplex stability , Hybridization
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1085752
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