Title of article
[2+2] Carbonylative cycloaddition catalyzed by palladium: stereoselective synthesis of β-lactams
Author/Authors
Luigino Troisi، نويسنده , , Luisella De Vitis، نويسنده , , Catia Granito، نويسنده , , Tullio Pilati، نويسنده , , Emanuela Pindinelli، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
6
From page
6895
To page
6900
Abstract
[2+2] Carbonylative cycloaddition of chiral imines to various allyl halides, under CO pressure, in the presence of Et3N, a catalytic amount of Pd(OAc)2 and PPh3 as ligand, are carried out. Separable diastereomeric mixtures of chiral alkenyl-β-lactams are isolated with good yields and high trans diastereoselections. Absolute configurations are assigned by X-ray measurements and 1H NMR spectroscopy.
Keywords
Carbonylative cycloaddition , Stereoselectivity , Chiral ?-lactams , Enantiopure imines
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1085885
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