Title of article
Synthesis of aziridinomitosenes through base-catalyzed conjugate addition
Author/Authors
Kazunari Tsuboike، نويسنده , , David J. Guerin، نويسنده , , Steven M. Mennen، نويسنده , , Scott J. Miller، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
8
From page
7367
To page
7374
Abstract
Synthesis of an aziridinomitosene core structure that relies on a facile tertiary-amine base-catalyzed azide conjugate addition is reported. Straightforward derivatization of the conjugate addition product affords the desired mitomycin ring system. Initial catalyst screens have identified peptides that afford the product with modest enantioselectivities.
Keywords
Aziridinomitosene , Conjugate addition , Organocatalyst , Peptide
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1086965
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