Title of article
Reaction between quinone and thiazolidine. A study on the formation mechanism of new antiproliferative quinolindiones
Author/Authors
Adele Bolognese، نويسنده , , Gaetano Correale، نويسنده , , Michele Manfra، نويسنده , , Antonio Lavecchia، نويسنده , , Ettore Novellino، نويسنده , , Vincenzo Barone، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
9
From page
8189
To page
8197
Abstract
Reaction between quinolinquinone and thiazolidine in basic medium was investigated. 2-Arylthiazolidine-4-carboxylic acid ethyl esters undergo two different cleavages in basic medium, yielding the 1-aryl-2-azadiene and a thiolic species. In the presence of quinolinquinone, the isomeric 1-aryl-3-ethoxycarbonyl-pyridoisoquinolin-5,10-diones and 3-amino-3-ethoxycarbonyl-dihydrothienoquinolin-4,9-diones are formed by a hetero-Diels–Alder reaction and 1,4-Michael addition reaction, respectively. A mechanism for the formation of the reaction products is presented.
Keywords
thiazolidine , Quinone , azadiene
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1087037
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