Title of article
Diastereoselective synthesis of 2,3,4,5-tetrasubstituted isoxazolidines via 1,3-dipolar cycloaddition
Author/Authors
Vellaisamy Sridharan، نويسنده , , Shanmugam Muthusubramanian، نويسنده , , Shanmugaperumal Sivasubramanian، نويسنده , , Kurt Polborn، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
12
From page
8881
To page
8892
Abstract
The 1,3-dipolar cycloaddition reactions of α-2-methoxyaryl nitrones with nitrostyrenes and chalcones have been investigated. The regiochemistry and stereochemistry of the resultant cycloadducts have been determined with the help of NMR spectroscopy and X-ray analysis. β-Nitrostyrenes add to nitrones to give two geometrical isomers, while the β-methyl-β-nitrostyrene gives a single isomer in relatively low yield. The chalcones give a single cycloadduct upon 1,3-dipolar addition.
Keywords
1 , 3-dipolar cycloaddition , ?-2-Methoxyaryl nitrones , Stereoselectivity , NMR and X-ray analysis
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1087100
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