Title of article
New sesterterpenes from Madagascan Lendenfeldia sponges
Author/Authors
Liat Chill، نويسنده , , Amira Rudi، نويسنده , , Maurice Aknin، نويسنده , , Shoshana Loya، نويسنده , , Amnon Hizi، نويسنده , , Yoel Kashman، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
8
From page
10619
To page
10626
Abstract
A new furanoterpene designated dehydrofurodendin and nine scalarane sesterterpenes of which four are new, were isolated from two different species of Madagascan sponges of the genus Lendenfeldia, both of which seem to be yet undescribed. The structure of the compounds was elucidated by interpretation of 1D and 2D NMR data. Dehydrofurodendin was found to be a potent inhibitor of HIV-1 RT. Several of the isolated scalaranes exhibited cyctotoxicity against several human tumor cells.
Keywords
Sesterterpenes , Cytotoxicity , Lendenfeldia , HIV-1 RT inhibition , Marine sponges
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1087273
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