An environmentally friendly α-hydroxyallylation reaction of the Garner aldehyde: a comparative assessment of alternative Barbier conditions

The reaction of 3-bromo-propenyl acetate with the Garner aldehyde promoted by zinc or indium metal is studied in different solvents; besides the stereoselectivity, attention is focused on a comparative environmental assessment of different experiments carried out in NH4Cl, THF or DMF, using green chemistry metrics and a qualitative analysis of environmental risks.