Title of article
Synthesis of 5-(7-hydroxyhept-3-enyl)-1,2-dithiolan-3-one 1-oxide, a core functionality of antibiotic leinamycin
Author/Authors
Alex H.F Lee، نويسنده , , Albert S.C. Chan، نويسنده , , Tianhu Li، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
7
From page
833
To page
839
Abstract
5-(7-Hydroxyhept-3-enyl)-1,2-dithiolan-3-one 1-oxide possessing both the 1,2-dithiolan-3-one 1-oxide five-membered ring and the double bond at the gamma position of the heterocycle, characteristic of the antibiotic leinamycin, was synthesized. In addition, the activated ester form of was prepared that may be useful for coupling to certain DNA-binding agents.
Keywords
antibiotic leinamycin , activated ester , Heterocycle , Antisense oligonucleotide , 1 , 2-dithiolan-3-one 1-oxide , DNA-cleaving agent
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1087493
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