Author/Authors :
Masashi Tsuda، نويسنده , , Tadashi Endo، نويسنده , , Marinela Perpelescu، نويسنده , , Shonen Yoshida، نويسنده , , Kenji Watanabe*، نويسنده , , Jane Fromont، نويسنده , , Yuzuru Mikami، نويسنده , , Junichi Kobayashi، نويسنده ,
Abstract :
A new cytotoxic oxylipin, plakevulin A (), possessing a cyclopentene ring and a levulinyl ester has been isolated from an Okinawan marine sponge Plakortis sp. The structure was elucidated on the basis of spectroscopic data, and the absolute configurations at three chiral centers were assigned by spectroscopic data of the reductive product of and a modified Mosherʹs method. Plakevulin A () exhibited inhibitory activity against DNA polymerases α and γ.
