Title of article
Carbonyl-yne reactions of 3,3,3-trifluoropyruvates
Author/Authors
Alexander M. Golubev، نويسنده , , Natalia N Sergeeva، نويسنده , , Lothar Hennig، نويسنده , , Alexey F Kolomiets، نويسنده , , Klaus Bürger، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
6
From page
1389
To page
1394
Abstract
An efficient synthesis of trifluoromethyl-containing 2,3-allenols via carbonyl-yne reaction of 3,3,3-trifluoropyruvates with acetylenes is described. In the presence of MgBr2·Et2O the reaction of methyl trifluoropyruvate with hex-1-yne proceeds diastereoselectively. Trifluoromethyl-substituted 2,3-allenols can be stereoselectively transformed into trifluoromethyl-substituted 2,5-dihydrofurans on treatment with AgNO3.
Keywords
fluoroalkyl-substituted 2 , 5-dihydrofurans , carbonyl-yne reaction , 2 , 3 , 3-allenols , 3 , 3-trifluoropyruvates
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1087551
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