Title of article
Total synthesis of mycophenolic acid
Author/Authors
Adri?n Covarrubias-Z??iga، نويسنده , , Armando Gonzalez-Lucas، نويسنده , , Mireya M. Dom??nguez، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
6
From page
1989
To page
1994
Abstract
A convergent total synthesis of the natural compound mycophenolic acid is described. The synthetic strategy for the construction of the hexasubstituted aromatic nucleus was based on a ring annulation sequence, involving a Michael addition reaction and intramolecular Dieckmann condensation reaction in situ as the key step. Subsequent transformations of the substituents afforded the target mycophenolic acid .
Keywords
Mycophenolic acid , Michael addition , Dieckmann condensation
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1087616
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