Title of article :
Dynamic thermodynamic resolution of N-methylpseudoephedrine α-bromo esters for asymmetric syntheses of α-hydroxy carboxylic acid derivatives
Author/Authors :
Jiyoun Nam، نويسنده , , Sang-kuk Lee، نويسنده , , Yong-Sun Park and Sang Joon Kim، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Pages :
5
From page :
2397
To page :
2401
Abstract :
An example of dynamic thermodynamic resolution in the nucleophilic substitution reactions of α-bromo esters with an oxygen nucleophile is described. Temperature controlled epimerization–substitution sequence provides a practical protocol for the preparation of highly enantioenriched α-hydroxy carboxylic acid derivatives up to 72% yield with 99:1 er.
Keywords :
dynamic thermodynamic resolution , Nucleophilic substitution , asymmetric syntheses , ?-hydroxy carboxylic acid , chiral auxiliaries
Journal title :
Tetrahedron
Serial Year :
2003
Journal title :
Tetrahedron
Record number :
1087656
Link To Document :
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