Author/Authors :
Thierry Durand، نويسنده , , Olivier Henry، نويسنده , , Alexandre Guy، نويسنده , , Arlène Roland، نويسنده , , Jean-Pierre Vidal، نويسنده , , Jean Claude Rossi، نويسنده ,
Abstract :
Radical cyclization of acyclic 1-substituted-2,4-dihydroxylated 5-hexenyl radicals produced functionalized cyclopentane derivatives. These cyclopentanic precursors after different protection/deprotection reactions followed by Wittig and Horner–Wadsworth–Emmons coupling reactions led to the main urinary tetranor metabolites of 15-F2t-isoprostane (8-epi-PGF2α).
Keywords :
tetranor metabolites , cyclopentane precursors , 15-F26-isoprostane , Radical cyclization
