Title of article
Preparation of 5-diaminomethylenebarbiturates by barbituric acid addition to carbodiimides
Author/Authors
Branko S. Jursic، نويسنده , , Fred Douelle، نويسنده , , Edwin D. Stevens، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
6
From page
3427
To page
3432
Abstract
Through NMR spectroscopic monitoring of barbituric acid addition to carbodiimide, a general synthetic procedure for the preparation of 5-diaminomethylenebarbiturates (DABA) was developed. This procedure is very simple and applicable to the preparation of large quantities of DABA derivatives. Through an X-ray structural study of one of the DABA derivatives, it was established that these compounds have an ylide-type structure with strong charge separation within the molecule.
Keywords
barbituric acid , 5-diaminomethylenebarbiturates , immuno-modulating agents
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1087757
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