Author/Authors :
Ugo Chiacchio، نويسنده , , Antonino Corsaro، نويسنده , , Juan Mates، نويسنده , , Pedro Merino، نويسنده , , Anna Piperno، نويسنده , , Antonio Rescifina، نويسنده , , Giovanni Romeo، نويسنده , , Roberto Romeo، نويسنده , , Tomas Tejero، نويسنده ,
Abstract :
A new class of modified C-nucleosides has been synthesized according to the 1,3-dipolar cycloaddition methodology. The obtained compounds are structurally related to natural pseudouridine, where the sugar moiety is replaced by an isoxazolidine ring. Different experimental conditions, and the effect of additives on the cycloaddition process, have been examined; the best results were obtained when the cycloaddition reaction was performed under microwave irradiation
