Author/Authors :
Ana R D??az-Marrero، نويسنده , , Enrique Dorta، نويسنده , , Mercedes Cueto، نويسنده , , Juana Rovirosa، نويسنده , , Aurelio San-Mart??n، نويسنده , , Alberto Loyola، نويسنده , , José Darias، نويسنده ,
Abstract :
Four new labdane diterpenes, , with an unusual oxidation pattern have been isolated from the marine pulmonate Trimusculus peruvianus. The structure and stereochemistry of these compounds were determined by spectroscopic data and chemical transformations. The absolute stereochemistry of was assigned by application of the modified Mosher method. These compounds exhibit in vitro moderate cytotoxic activity against human colon carcinoma cell lines.
