Author/Authors :
Lovely Begum، نويسنده , , Julian M Box، نويسنده , , Michael G.B. Drew، نويسنده , , Laurence M. Harwood and others، نويسنده , , Jane L Humphreys، نويسنده , , David J Lowes، نويسنده , , Gareth A Morris، نويسنده , , Perrine M Redon، نويسنده , , Francine M Walker، نويسنده , , Roger C. Whitehead، نويسنده ,
Abstract :
Investigations into the quinate to shikimate transformation have been carried out, the results of which have been exploited in the synthesis of a novel difluoromethylene homologue of shikimic acid from (−)-quinic acid. Martinʹs sulfurane {Ph2S[OC(CF3)2Ph]2} was the reagent of choice for the key dehydration step of this synthesis. The results of investigations into the synthesis of the important natural product analogue, 6,6-difluoroshikimic acid are also reported.
