Title of article
New 5-(2-ethenylsubstituted)-3(2H)-furanones with in vitro antiproliferative activity
Author/Authors
Stefano Chimichi، نويسنده , , Marco Boccalini، نويسنده , , Barbara Cosimelli، نويسنده , , Francesco DallʹAcqua، نويسنده , , Giampietro Viola، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
9
From page
5215
To page
5223
Abstract
A convenient route to new 3(2H)-furanones is described through hydrogenolysis and subsequent acidic hydrolysis of isoxazoles. The antiproliferative activity of title compounds were evaluated against leukemia-, carcinoma-, neuroblastoma-, and sarcoma-derived human cell lines in comparison to the natural compound geiparvarin. The structure activity relationship indicated that the maximum in vitro antiproliferative activity correlates with the presence of a heterocyclic ring on the ethenyl moiety.
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1087945
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