Author/Authors :
Lisa M. Frey، نويسنده , , Karen M Marcantonio، نويسنده , , Cheng-yi Chen، نويسنده , , Debra C. Wallace، نويسنده , , Jerry A Murry، نويسنده , , Lushi Tan، نويسنده , , Weirong Chen، نويسنده , , Ulf H Dolling، نويسنده , , Edward J.J Grabowski، نويسنده ,
Abstract :
Compound is a uniquely substituted ketone prepared via addition of a thiazole anion to an aromatic nitrile in good overall yield. An exploration into the generality of the addition of thiazole anions to nitriles allowed us to make a variety of thiazole ketones in good to excellent yields. The non-odorous thiolate-mediated demethylation reaction used in the synthesis of is also presented.
Keywords :
thiazole ketone , Anion , Reaction , difluoromethylation , Demethylation
