Author/Authors :
Luisella De Vitis، نويسنده , , Saverio Florio، نويسنده , , Catia Granito، نويسنده , , Ludovico Ronzini، نويسنده , , Luigino Troisi، نويسنده , , Vito Capriati، نويسنده , , Renzo Luisi، نويسنده , , Tullio Pilati، نويسنده ,
Abstract :
Lithiated (α-chloroalkyl)heterocycles, generated by deprotonation with LDA at −78 °C in THF, add to various enantiopure imines affording ‘one pot’ chiral heterosubstituted aziridines in a diastereoselective manner. Lithiated heterosubstituted aziridines, obtained by deprotonation of the corresponding aziridines with n-BuLi at −78 °C in THF, were trapped by electrophiles (D2O or CH3I) with high stereoselectivity.
