Title of article
Synthetic studies on the DEF-rings of FR182877 and hexacyclinic acid
Author/Authors
Paul A. Clarke، نويسنده , , Matthew Grist، نويسنده , , Mark Ebden، نويسنده , , Marie-Claire Wilson، نويسنده , , Alexander J. Blake، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
11
From page
353
To page
363
Abstract
A synthesis of model DEF-rings of the polyketide anti tumor natural products FR182877 and hexacyclinic acid has been achieved. The key steps in the synthesis are an intramolecular Pd(0) catalyzed allylic substitution reaction, which was used to generate a 9-membered carbocycle, and a novel transannular iodocyclization reaction which furnished the DF-rings of both natural products.
Keywords
transannular , Iodocyclisation , Medium sized rings , Natural products
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1088256
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