Efficient synthesis of various acycloalkenyl derivatives of pyrimidine using cross-metathesis and Pd(0) methodologies

Novel acyclonucleosides (, , and ) have been prepared using Pd(0) and cross-metathesis methodologies. The allylic N-alkylation under Tsuji–Trost conditions was used to introduce the nucleobase, while the Suzuki–Miyaura reaction afforded C-5 substituted uracil analogues. The cross-metathesis performed with a ruthenium catalyst was used to provide new acycloalkenyl nucleosides. The antiviral activities of all final compounds have been evaluated.