Author/Authors :
Bing-Nan Zhou، نويسنده , , Shoubin Tang، نويسنده , , Randall K. Johnson، نويسنده , , Michael P. Mattern، نويسنده , , John S. Lazo، نويسنده , , Elizabeth R. Sharlow، نويسنده , , Kim Harich، نويسنده , , David G.I Kingston، نويسنده ,
Abstract :
A crude extract of a marine alga showed activity against the enzyme Myt1 kinase. Bioassay-directed fractionation led to the isolation of two bioactive glycoglycerolipids. Lipid was identified as sn-1,2-dipalmityl-3-(N-palmityl-6-deoxy-6-amino-α-d-glucosyl) glycerol and lipid as sn-1-palmityl-2-myristyl-3-(N-stearyl-6-deoxy-6-aminoglucosyl)glycerol. Compounds and had IC50 values of 0.12 and 0.43 μg/mL, respectively, in the Myt1 kinase inhibitory bioassay, and were inactive against Akt and Chk1 kinases.
