Cyclodextrin assisted enantiomeric recognition of benzo[de]isoquinoline-1,3-dione derived amino acids

Spectroscopic evidence for enantiomeric recognition of properly modified amino acids through the cyclodextrin assisted formation of polymer like self-assemblies is presented. The requirements for the formation of these assemblies through aromatic π–π stacking are discussed. It is suggested that this approach can be used for enantiomeric separation of chiral compounds that contain both electron-rich and electron-poor moieties.