Title of article
The trimethylsilyl xylyl (TIX) ether: a useful protecting group for alcohols
Author/Authors
Ch Raji Reddy، نويسنده , , Amar G. Chittiboyina، نويسنده , , Rajashaker Kache، نويسنده , , Jae Chul Jung، نويسنده , , E. Blake Watkins، نويسنده , , Mitchell A. Avery، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
7
From page
1289
To page
1295
Abstract
A new protecting group for alcohols, the p-trimethylsilyl xylyl (TIX) group has been developed. The TIX group is used to protect various alcohols under acidic as well as basic conditions. The protected ethers thus formed had noteworthy chemoselectivity upon deprotection in the presence of other benzyl ethers and commonly used protecting groups. The stability of the TIX group towards various reagents has also been examined.
Keywords
Piperazino-piperidine nucleus , CCR5 antagonist , Reductive amination , Chiral pool , 4-Substituent-4-aminopiperidine
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1088352
Link To Document