5′-Noraristeromycin derivatives isomeric to aristeromycin and 2′-deoxyaristeromycin

A straightforward synthesis of (1S,2R,3R,4R)-4-(6-aminopurin-9-yl)-2-hydroxymethylcyclopentane-1,3-diol (), an isomer of aristeromycin, and its 2′-deoxy derivative from readily available disubstituted cyclopentenes is presented. An antiviral analysis of showed it to have significant activity versus Epstein–Barr virus (IC50 0.62 μg/mL in the Elisa assay) and to be free of cytotoxicity effects against the host cells. In a much less comprehensive antiviral analysis, also was active towards Epstein–Barr (IC50 7.58 μg/mL in the Elisa assay) but this was accompanied by cellular toxicity.