Title of article
An expedient synthesis of 3-acyltetramic acids of the melophlin family from α-aminoesters and immobilized Ph3PCCO
Author/Authors
Rainer Schobert، نويسنده , , Carsten Jagusch، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
7
From page
2301
To page
2307
Abstract
The naturally occurring 3-acyltetramic acids (3-acylpyrrolidine-2,4-diones) melophlin A, B, C and G were prepared in few steps from α-aminoesters or their hydrochlorides by cyclization with Ph3PCCO under mild conditions. The employment of immobilized, polystyrene-bound ylide greatly simplifies the removal of by-product Ph3PO and of other impurities. Various 3-acylation methods were assessed.
Keywords
phosphorus ylides , Melophlins , Immobilized reagents , Microwave , tetramic acids , Solid phase organic synthesis
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1088457
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