Title of article
Pyridino-directed lithiation of anisylpyridines: new access to functional pyridylphenols
Author/Authors
Michaël Parmentier، نويسنده , , Philippe Gros، نويسنده , , Yves Fort، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
9
From page
3261
To page
3269
Abstract
The lithiation of nine anisylpyridines has been studied. While usual reagents did not react or gave addition products on pyridine ring, the BuLi-LiDMAE (LiDMAE=Me2N(CH2)2OLi) superbase induced exclusive pyridino directed metallation. The usefulness of this new reaction allowed the efficient preparation of a range of alpha functional pyridylphenols. A successful subsequent cyclisation of an appropriate isomer into corresponding benzofuropyridine was also performed.
Keywords
Selective lithiation , Pyridino-direction , Anisylpyridines , Cyclization
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1088550
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