Title of article
An efficient entry to pyrrolo[1,2-b]isoquinolines and related systems through Parham cyclisation
Author/Authors
Javier Ruiz، نويسنده , , Ainhoa Ardeo، نويسنده , , Roberto Ignacio، نويسنده , , Nuria Sotomayor، نويسنده , , Esther Lete، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
14
From page
3311
To page
3324
Abstract
Aryllithiums generated by lithium–iodine exchange undergo intramolecular cyclisation to give pyrrolo[1,2-b]isoquinolines, in high yields. The best results were obtained when Weinreb or morpholine amides were used as internal electrophiles. The procedure has been extended to the preparation of seven and eight membered rings, opening a route to benzazepine and benzazocine skeletons.
Keywords
Parham cyclisation , lithiation , 2-b]isoquinoline , Lithium–halogen exchange
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1088555
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